In this guide, I will outline the requirements to access and defeat the 5 endgame bosses in Diablo 4, along with tips on farming the necessary materials efficiently. Defeating these bosses will reward you with the most powerful gear drops in the game and increase your chances of getting rare "Uber" unique items, helping you earn Diablo 4 fast and safe gold through item sales.

Solo Bosses

The Beast and the Ice

This boss is found in the Glacial Fisher Nightmare dungeon, which requires:

• 30,000 gold
• 250 Cidral powder
• 9 Distilled Fear (dropped from Nightmare dungeons tier 30+)

You will need to reach Torment tier 4 to access high-level Nightmare dungeons. Distilled Fear are not guaranteed drops, so be prepared to run multiple dungeons.

Lord Zir the Dark Master

Defeat Lord Zir by collecting 9 Exquisite Blood, obtainable from Torment tier 4 Legion Events and World Bosses. Check sites like Hellties for event timers. Fight Lord Zir in the Darkened Way in Fractured Peaks.

Group Bosses

Gregwar the Penitent

Requires 5 Living Steel, obtained from opening Living Steel chests (300 Cinders each) during Helltide events. Check event timers and open at least 2 chests. Fight Gregwar in the Hall of the Penitent in the Dry Steps.

Varan

Requires:

• 1 Gurgling Head
• 1 Blackened Femur
• 1 Trembling Hand
• 1 Malignant Heart

Items can drop randomly or be obtained via Grim Favors and crafting. Fight Varan next to the Tree of Whispers in Howzer. He drops a Mucus Slick Egg.

Duriel

Requires:

• 2 Mucus Slick Eggs (from Varan)
• 2 Shards of Agony (from Gregwar)

Be at least level 87 for this level 100 boss. He's found in the Gaping Crevice in Ketan and drops high-level equipment.

Tips for Farming Materials Efficiently

Prioritize Torment tier 4 for higher drop rates. Continue unlocking Nightmare dungeons for Distilled Fear. Use Hellties to find lucrative Helltide/Legion events. Consider crafting workarounds if a specific material is evading you. Focus boss farming around typical real-life schedules to catch multiple Helltide rotations.

Comparison of Helltide/Blood Harvest Yields:

In summary, focus on Blood Harvest for faster boss farming. Only do Helltides if you catch Living Steel chest locations in time. Good luck and have fun defeating the endgame bosses!